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SimpleDesign: A Joint Model for Protein Sequence and Structure Codesign

Proteins are fundamental to biological processes, with their function determined by the complex interplay between the amino acid sequence and the three-dimensional structure. Developing generative models capable of understanding this intrinsically multi-modal relationship is crucial for fields like drug discovery and protein engineering. Existing models often rely on a multi-stage training process where autoencoders that…

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AI

Putting Captions to the Test: Evaluating Video Caption Quality through Multiple-Choice Question Answering

Evaluating video captioning remains a critical challenge for Visual Large Language Models (VLLMs). Existing metrics primarily rely on matching generated text against ground-truth references. This paradigm suffers from the “one-to-many” nature of video description, where high-quality captions are often penalized for lexical mismatches or valid shifts in visual focus. Furthermore, such assessments are typically one-dimensional,…

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AI

DiscoSign: Discourse-Aware Text to Sign Language Gloss Translation

Sign language processing systems have traditionally operated at the sentence level, ignoring critical discourse phenomena fundamental to sign language comprehension. We introduce DiscoSign, a computational approach for discourse-aware text to sign language gloss translation grounded in linguistic research. We address three key phenomena within our modular Large Language Model (LLM)-based translation framework: (i) spatial coreference…

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Apps

Announcing new builds for 11 September 2026

Hello Windows Insiders, Today, we’re releasing new Windows 11 Insider Preview builds to the Beta, Experimental, and Release Preview channels. New builds this week Select your channel below to view its release notes: B The post Announcing new builds for 11 September 2026 appeared first on Windows Blog.

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